Russians want business, not charity

Waste Not , Want Not !

Computer systems are not the monolithic machines they used to be. In the early days of computer science (until the late 70s), most computer systems included exactly one component to perform a given task: one (type of) disc for persistence, one CPU for processing and one volatile RAM to hold intermediate data. Today, the architecture has developed into a heterogeneous landscape of components: di...

Waste not, want not.

As of the writing of this Editorial, the current JCI Editorial Board has evaluated approximately 7,000 manuscripts over the past 22 months for their suitability for publication in our journal. While many of you have received a negative decision on your manuscript, I suspect few are aware of the changes we have made to our review process to limit reviewers' requests for what is in our view unnec...

Metabolic syndrome: Waist not want not.

Medication costs in Wisconsin Medicaid: Waste not, want not?

Waste Not, Want Not: Why Rarefying Microbiome Data Is Inadmissible

Current practice in the normalization of microbiome count data is inefficient in the statistical sense. For apparently historical reasons, the common approach is either to use simple proportions (which does not address heteroscedasticity) or to use rarefying of counts, even though both of these approaches are inappropriate for detection of differentially abundant species. Well-established stati...